I'm not sure how I would handle the overloading of the plane. On one hand, I kind of want that to be in the pilot's hands and make him roll a skill check. On the other hand, maybe everyone involved should just roll a save vs. plot to stay alive. A combination of the two would have the pilot rolling the skill check and the passengers on the wings making saves vs. plot (or maybe science, to avoid wind shear).
Also worth noting is that formulas could be considered treasure -- something with monetary value, but little value as a trophy -- to a Hero.
Again, I question the use of madman as a mobster type, as Professor Dwyer really seems to just be a mad doctor here. Mad doctors get an entry separate from mad scientists in 2nd edition and will have a skill in brain transplants.
There's also passing reference to two trophy items here -- an electro magnet that can guide planes off-course, and an incandescent (as opposed to fluorescent?) death ray that seems to focus on killing vegetation.
Realistically, the mobsters don't want to spend all their time on a cramped submarine, which is why their true hideout is the schooner. The schooner appears to be an ordinary trophy-transport item.
(Scans courtesy of Comic Book Plus)